Simparica Trio


EntirelyPets Pharmacy

All-in-One Protection for Heartworms, Fleas, and Ticks

Simparica Trio is a vet-recommended monthly chewable that provides broad-spectrum protection against heartworms, fleas, ticks, and intestinal parasites like hookworms and roundworms. Trusted by pet owners and veterinarians alike, it’s a convenient single-tablet solution for year-round protection.

What Is Simparica Trio?

Simparica Trio is a once-monthly chewable medication for dogs that combines three active ingredients: sarolaner (flea/tick killer), moxidectin (heartworm prevention), and pyrantel (intestinal worm treatment). It’s designed to simplify your dog’s parasite prevention routine with one tasty, easy-to-give tablet.

Key Benefits

Pros

  • Covers heartworms, fleas, ticks, and worms in one dose
  • Highly palatable for most dogs
  • Trusted brand with clinical backing
  • Reduces need for multiple medications

Cons

  • Requires a vet prescription
  • May cause mild side effects in some dogs (e.g., vomiting, diarrhea)
  • Not suitable for puppies under 8 weeks or under 2.8 lbs

How It Works
Simparica Trio is a monthly chewable tablet that offers triple protection using sarolaner, moxidectin, and pyrantel. Sarolaner kills fleas and ticks by affecting their nervous systems, moxidectin prevents heartworm disease, and pyrantel eliminates intestinal parasites like roundworms and hookworms. It begins working within 4–8 hours and provides 30 days of protection.

Who It’s For
Ideal for dogs needing comprehensive parasite control in a single monthly dose. Approved for dogs 8 weeks and older weighing at least 2.8 pounds. Not recommended for dogs with a history of seizures or known sensitivity to isoxazolines unless prescribed under veterinary supervision.

Real-World Use

Pet owners report high satisfaction with Simparica Trio for simplifying their monthly parasite prevention. Dogs typically enjoy the chew, and results are reliable. Vets appreciate the comprehensive coverage in a single dose, reducing the risk of missed treatments or parasite gaps.

All-in-one protection gives peace of mind — Simparica Trio makes monthly prevention simple and effective.

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